Publications

Wu B, Qi L, Chiang H-C, Pan, H, Zhang X, Greenbaum A, Stark E, Wang L-J, Chen C, Haddad B, Clagett D, Isaacs C, Elledge R, Horvath A, Hu Y, Li R. (2022) BRCA1 Deficiency in Mature CD8 + T Lymphocytes Impairs Antitumor Immunity. J ImmunoTher Cancer 11:e005852.

Qi L, Chakravarthy R, Li MM, Deng C-X, Li R, Hu Y. (2022) Phosphorylation of BRCA1 by ATM upon Double-Strand Breaks Impacts ATM Function in End-Resection: A Potential Feedback Loop. iScience 25:104944.

Wu B, Zhang X, Chiang H-C, Pan, H, Yuan B, Mitra P, Qi L, Simonyan H, Young CN,

Yvon E, Hu Y, Zhang N, Li R. (2022) RNA polymerase II pausing factor NELF in CD8 + T cells promotes antitumor immunity. Nat Commun 13:2155.

Mateo F, He Z, Mei L, de Garibay GR, Herranz C, García N, Lorentzian A, Baiges A,

Blommaert E, Gomez A, Mirallas O, Garrido-Utrilla A, Palomero L, Espín R, Extremera

A, Monsó MTS, Petit A, Consortium of Investigators of Modifiers of BRCA1/2 CIMBA, Li

R, Brunet J, Chen K, Tan S, Eaves C, McCloskey C, Hakem R, Khokha R, Lange P,

Lázaro C, Maxwell C, Pujana M. (2022) Modification of BRCA1-associated breast cancer risk by HMMR overexpression. Nat Commun 13:1895

Kornepati AVR, Boyd JT, Murray CE, Saifetyarova J, de la Peña Avalos B, Rogers CM, Bai H, Padron AS, Liao Y, Ontiveros C, Svatek RS, Hromas R, Li R, Hu Y, Conejo- Garcia JR, Vadlamudi RK, Zhao W, Dray E, Sung P, Curiel TJ. (2022) Tumor-intrinsic programmed death-ligand 1 promotes DNA repair by homologous recombination in distinct cancers and can suppress PARP inhibitor synthetic lethality. Cancer Res 82:2156

Ou J, Guan X, Wanf J, Wanf T, Zhang B, Li R, Xu H, Hu X, Guo X-K. (2021) Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity. Mucosal Immunol 15:279

Young IC, Wu B, Andricovich J, Chuang ST, Li R, Tzatsos A, Wu MY, Wu RC. (2021)

Differentiation of Fetal Hematopoietic Stem Cells Requires ARID4B to Restrict Autocrine

KITLG/KIT-Src Signaling. Cell Reports 37:110036

Sun X, Wu B, Chiang H-C, Deng H, Zhang X, Xiong W, Liu J, Rozeboom AM, Harris B, Blommaert E, Gomez A, Garcia RE, Zhou Y, Mitra P, Prevost M, Zhang D, Banik D, Isaacs C, Berry D, Lai C, Chaldekas K, Latham PS, Brantner CA, Popratiloff A, Jin VX, Zhang N, Hu Y, Pujana MA * , Curiel TJ * , An Z * , Li R * . (2021) Tumour DDR1 Promotes Collagen Fibre Alignment to Instigate Immune Exclusion. Nature 599:673 (*co-corresponding authors).

Yang J, Qi L, Chiang H-C, Yuan B, Li R, Hu Y. (2021) BRCA1 Antibodies Matter, Intl J Biol Sci. 17:3239.

Yuan B*, Yang J, Dubeau L, Hu Y, Li R * . (2021) A Phosphotyrosine Switch in Estrogen Receptor b Is Required for Mouse Ovarian Function. Front. Cell Dev. Biol. 9:649087.

Yuan B, Clark CA, Wu B, Yang J, Drerup JM, Li, T, Jin V, Hu Y, Curiel TJ * , Li R * . (2021) Estrogen Receptor Beta Signaling in CD8 + T Cells Boosts T Cell Receptor Activation and Anti-tumor Immunity through a Phosphotyrosine Switch. J ImmunoTher Cancer 9(1):e001932 (*co-corresponding authors).

Zhang D, Reyes RM, Osta E, Kari S, Gupta HB, Padron AS, Komepati AVR, Kancharla A, Sun X, Deng Y, Wu B, Vadlamudi R, Li R, Curiel TJ. (2021) Bladder cancer cell- intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy. Cancer Medicine 10(6):2137.

Yang Y, Choppavarapu L, Fang, K, Naeini, AS, Nosirov B, Li J, Yang K, He Z, Zhou Y, Schiff R, Li R, Hu Y, Wang J, Jin VX. (2020) The 3D genomic landscape of differential response to EGFR/HER2 inhibition in endocrine-resistant breast cancer cells. Biochim Biophys Acta Gene Regul Mech 1863(11):194631.

Wu B, Chiang H-C, Sun X, Yuan B, Mitra P, Hu Y, Curiel TJ * , Li R * . (2020) Genetic Ablation of Adipocyte PD-L1 Reduces Tumor Growth but Accentuates Obesity- Associated Inflammation. J ImmunoTher Cancer 8(2):e000964 (*co-corresponding authors).

Yu L, Zhang B, Deochand D, Sacta MA, Coppo M, Shang Y, Guo Z, Zeng X, Rollins D,Tharmalingam B, Li R, Chinenov Y, Rogatsky I, Hu X. (2020) Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression. Nat Commun. 11:2286.

Cui H, Esworthy T, Zhou X, Glazer RI, Li R, Zhang LG. (2020) Engineering a Novel 3D Printed Vascularized Tissue Model for Investigating Breast Cancer Metastasis to Bone. Adv Healthc Mater.  9:1900924.

Wu B, Sun X, Yuan B, Ge F, Gupta HB, Chiang H-C, Li J, Hu Y, Curiel TJ * , Li R * . (2019) PPARg Inhibition Boosts Efficacy of Immune Checkpoint Immunotherapy Against Murine Melanoma in a Sexually Dimorphic Manner. Intl J Biol Sci. 16:1526 (*co-

corresponding authors).

Chiang H-C, Zhang X, Li J, Zhao X, Chen J, Wang HT-H, Jatoi I, Brenner A, Hu Y* and Li R*. (2019) BRCA1-Associated R-Loop Affects Transcription and Differentiation in Breast Luminal Epithelial Cells. Nucleic Acids Res. 47:5086 (*co-corresponding authors).

Zhang X, Wang Y, Chiang H-C, Hsieh Y-P, Lu C, Park BH, Jatoi I, Jin VX*, Hu Y* and Li R*. (2019) BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells. Breast Cancer Res. 21:51 (*co- corresponding authors)

Zhang X*, Li R*. (2018) BRCA1-Dependent Transcriptional Regulation: Implication in Tissue-SpecificTumor Suppression. Cancers (Basel) 10:513 (*co-corresponding authors)

Wu B, Sun X, Gupta HB, Yuan B, Li J, Ge F, Chiang H-C, Zhang X, Zhang C, Zhang D, Yang J, Hu Y, Curiel TJ*, Li R*. (2018) Adipose PD-L1 Modulates PD-1/PD-L1 Checkpoint Blockade Immunotherapy Efficacy in Breast Cancer. Oncoimmunology. DOI: 10.1080/2162402X.2018.1500107 (*co-corresponding authors)

Yun H, Bedolla R, Horning A, Li R, Chiang H-C, Huang T-H, Reddick R, Olumi AF, Ghosh R, Kumar A (2018) BRCA1 interacting protein COBRA1 facilitates adaptation to castrate-resistant growth conditions. Intl. J. Mol. Sci. 19(7). pii: E2104.

Sacta MA, Tharmalingam B, Coppo M, Rollins DA, Deochand DK, Benjamin B, Yu L, Zhang B, Hu X, Li R, Chinenov Y, Rogatsky I. (2018) Gene-specific mechanisms direct Glucocorticoid Receptor-driven repression of inflammatory response genes in

macrophages. eLife. 9;7. pii: e34864.

Sun X, Gupta K, Wu B, Zhang D, Yuan B, Zhang X, Chiang H-C, Zhang C, Curiel TJ, Bendeck M, Hursting S, Hu Y*, Li R*. (2018) Tumor-Extrinsic DDR1 Promotes Mammary Tumor Growth by Regulating Adipose Stromal IL-6 Production. J. Biol. Chem. 293:2841 (*co-corresponding authors)

Chiang H-C, Zhang X, Zhao X, Zhang C, Chen, J, Garza P, Smith S, Ludwig T, Baer RJ, Li R*, Hu Y*. (2018) Gene-Specific Genetic Complementation between Brca1 and Cobra1 during Mouse Mammary Gland Development. Sci. Rep. 8:2731 (*co-corresponding authors)

Padrón A, Hurez V, Gupta HB, Clark CA, Pandeswara SL, Yuan B, Svatek RS, Turk MJ, Drerup JM, Li R, Curiel, TJ. (2018) Age effects of distinct immune checkpoint blockade treatments in a mouse melanoma model. Experimental Gerontology 105:146.

Wu Y, Dr. Zhang Z, Cenciarini ME, Proietti CJ, Amasino MF, Hong T, Yang M, Liao Y,

Chiang H-C, Kaklamani V, Jeselsohn R, Vadlamudi RK, Huang TH, Li R, Angelis CD, Fu X, Elizalde PV, Schiff R, Brown M, Xu K. (2017) Transcriptional Axis of EZH2-ERα- GREB1 Regulates Tamoxifen Resistance in Breast Cancer. Cancer Res. 78:671.

Zhang X, Chiang H-C, Wang Y, Zhang C, Smith S, Zhao X, Nair S, Michalek J, Jatoi J, Lautner M, Oliver B, Wang H, Petit A, Soler T, Brunet J, Mateo F, Pujana MA, Poggi E, Chaldekas K, Isaacs C, Peshkin BN, Ochoa O, Chedin F, Theoharis C, Sun L-Z, CurielTJ, Elledge R, Jin VX*, Hu , Y*, Li R*. (2017) Attenuation of RNA Polymerase II Pausing Mitigates BRCA1-Associated R-loop Accumulation and Tumorigenesis. Nat Commun. 8:15908. (*co-corresponding authors)

Liu J, Viswanadhapalli S, Garcia L, Zhou M, Kost E, Tekmal RR, Li R, Rao MK, Curiel T, Vadlamudi RK, and Sareddy GR. (2017) Therapeutic utility of natural estrogen receptor beta agonists on ovarian cancer. Oncotarget 8:50002-50014.

Gupta HB, Clark CA, Yuan B, Sareddy G, Pandeswara S, Padron AS, Hurez V, Conejo- Garcia J, Vadlamudi R, Li R, Curiel TJ. (2016) Tumor cell-intrinsic PD-L1 promotes tumor-initiating cell generation and functions in melanoma and ovarian cancer. Signal Transduct Target Ther. 1:16030.

Clark CA, Gupta H, Sareddy GR, Pandeswara S, Lao S, Yuan B, Drerup JM, Padron A, Conejo-Garcia JR, Murthy K, Liu Y, Turk MJ, Thedieck K, Hurez V, Li R, Vadlamudi RK, Curiel TJ. (2016) Tumor-intrinsic PD-L1 signals regulate cell growth, pathogenesis and autophagy in ovarian cancer and melanoma. Cancer Res. 76:6964-6974.

Yuan B, Cheng L, Gupta K, Chiang H-C, Gupta H, Sareddy GR, Wang D, Lathrop K, Elledge R, Wang P, McHardy S, Vadlamudi R, Curiel TJ, Hu Y, Ye Q, Li R. (2016) Tyrosine Phosphorylation Regulates ERb Ubiquitination, Protein Turnover, and Inhibition of Breast Cancer. Oncotarget. 7:42585-42597.

Nair S, Zhang X, Chiang H-C, Jahid MJ, Wang Y, Garza P, April C, Salathia N, Banerjee T, Alenazi FS, Ruan J, Fan J-B, Parvin JD, Jin VX, Hu Y*, Li R*. (2016) Genetic Suppression Reveals DNA Repair-Independent Antagonism between BRCA1 and COBRA1 in Mammary Gland Development. Nat Commun. 7:10913. (*co-

corresponding authors)

Chiang H-C, Elledge R, Li R, Hu Y (2015). Effects of radiation therapy on breast epithelial cells in BRCA1/2 mutation carriers. Breast Cancer 9:25-29. PMCID: PMC4454133

Pan H, Zhao X-Y, Zhang, X-W, Abouelsoud M, Sun J, April C, Amleh A, Fan J-B, Hu Y, Li R. (2015) Translational initiation at a non-AUG start codon for human and mouse negative elongation factor-B. Plos ONE 10:e0127422.

Long Parma D, Hughes DC, Ghosh S, Li R, Treviño-Whitaker RA, Ogden SM, Ramirez AG. (2015) Effects of six months of Yoga on inflammatory serum markers prognostic of recurrence risk in breast cancer survivors. Springerplus 26:143.

Parameswaran B, Chiang HC, Lu Y, Coates J, Deng CX, Baer R, Lin HK, Li R, Paull TT, and Hu Y. (2015) Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle 14:437-48.

Ghosh S, Gu F, Wang CM, Lin CL, Liu J, Wang H, Ravdin P, Hu Y, Huang TH, Li R.

(2014) Genome-wide DNA methylation profiling reveals parity-associated hypermethylation of FOXA1. Breast Cancer Res Treat. 147:653-9.

Yuan B, Cheng L, Chiang H-C, Xu X, Han Y, Su H, Wang L, Zhang B, Li J, Tekmal J, Li X, Xie X, Wang T, Tekmal RR, Curiel TJ, Yuan Z-Y, Elledge R, Hu Y, Ye Q, Li R. (2014) A phosphotyrosine switch determines the antitumor activity of ERb. J. Clin. Invest.124:3378. (highlighted in September 2014 issue of Cancer Discovery). PMCID:

PMC4109526.

Pan H, Qin K, Guo Z, Ma Y, April C, Gao X, Andrews TG, Bokov A, Zhang J, Chen Y, Weintraub ST, Fan J-B, Wang D, Hu Y, Aune GJ, Lindsey ML, Li R. (2014) Negative elongation factor controls energy homeostasis in cardiomyocytes. Cell Rep, 7:79. PMCID: PMC4277258.

Ghosh S, Hughes D, Ramirez A, Li, R. (2014) Association of Obesity and Circulating Adipose Stromal Cells Among Breast Cancer Survivors. Mol Biol Rep. 41:2907-16. PMCID: PMC4016178.

Cuevas BT, Hughes DC, Parma DL, Trevino RA, Ghosh S, Li R, Ramirez AG. (2013) Motivation, Exercise, and Stress in Breast Cancer Survivors. Support Care Cancer 22:911 917 PMCID: PMC3943705.

Luo M, Lu X, Zhu R, Zhang Z, Chow CC, Li R, Simons Jr SS. (2013) A Conserved Protein Motif Is Required for Full Modulatory Activity of Negative Elongation Factor Subunits NELF-A and NELF-B in Modifying Glucocorticoid Receptor-Regulated Gene Induction Properties. J. Biol. Chem.288:34055-72.

Hsu P-Y, Hsu H-K, Lan X, Juan L, Yan PS, Labanowska J, Heerema N, Hsiao T-H, Chiu Y-C, Chen Y, Liu Y, Li L, Li R, Thompson IM, Nephew KP, Sharp ZD, Kirma NB, Jin VX, Huang T H-M.  (2013) Amplification of distant estrogen response elements deregulates target genes associated with tamoxifen resistance in breast cancer. Cancer Cell 24:197.PMCID: PMC3890247.

Ghosh S, Ashcraft K, Jahid MJ, April C, Ghajar CM, Ruan J, Wang H, Foster M, Hughes, DC, Ramirez, AG, Huang T, Fan JB, Hughes, D, Ramirez A, Hu Y, Li R. (2013) Regulation of adipose estrogen output by mechanical stress. Nat Commun. 4:1821. PMCID: PMC3921626.

Chiang HC, Nair SJ, Yeh IT, Santillan AA, Hu Y, Elledge R, Li R. (2012) Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier. Exp Hematol Oncol. 1:31. PMID:23210696

Sun J, Pan H, Lei C, Yuan B, Nair SJ, April C, Parameswaran B, Klotzle B, Fan J-B, Ruan J, and Li R: (2011) Genetic and genomic analyses of an RNA polymerase II- pausing factor in regulation of mammalian transcription and cell growth. J Biol Chem. 286: 36248-57 [Epub 2011 Aug 24]. PMCID: PMC3196092.

Ghosh S, Kang T, Wang H, Hu Y, and Li R: (2011) Mechanical phenotype is important for stromal aromatase expression. Steroids, 76: 797-801, 2011. [Epub 2011 Mar 4]. PMCID: PMC3114299.

Vachon CM, Sasano H, Ghosh K, Brandt KR, Watson DA, Reynolds C, Lingle WL, Goss PE, Li R, Aiyar SE, Scott CG, Pankratz VS, Santen RJ, and Ingle JN: (2010) Aromatase immunoreactivity is increased in mammographically dense regions of the breast. Breast Cancer Res Treat. 125: 243-52. [Epub 2010 Jun 5]. PMCID: PMC2997154.

Ghosh S, Dean A, Walter M, Bao Y, Hu Y, Ruan J, and Li R: (2010) Cell density- dependent transcriptional activation of endocrine-related genes in human adipose tissue-derived stem cells. Exp Cell Res. 316: 2087-98. [Epub 2010 Apr 24]. PMCID: PMC2900480.

Ghosh S, Hu Y, and Li R: (2010) Cell density is a critical determinant of aromatase expression in adipose stromal cells. J Steroid Biochem Mol Biol. 118: 231-6. [Epub 2009 Dec 5] PMCID: PMC2826521.

Sun J and Li R. (2010) Human negative elongation factor activates transcription and regulates alternative transcription initiation. J Biol Chem. 285: 6443-52. [Epub 2009 Dec 22] PMCID: PMC 2825440.

Walter M, Liang S, Ghosh S, Hornsby PJ, and Li R: (2009) Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene, 28: 2745-55. [Epub 2009 Jun 1]. PMCID: PMC2806057.

Wang H, Li R, and Hu Y: (2009) The alternative noncoding exons 1 of aromatase (cyp19) gene modulate gene expression in a posttranscriptional manner. Endocrinology, 150: 3301-7. [Epub 2009 Mar 12]. PMCID: PMC2703541.

Ghosh S, Choudary A, Ghosh S, Musi N, Hu Y, and Li R: (2009) IKKb mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells. Mol Endocrinol. 23: 662-70. PMCID: PMC2675949.

Wen J, Li R, Lu Y, and Shupnik MA: (2009) Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions. Oncogene, 28: 575-86. PMCID: PMC2714665.

Amleh A, Nair SJ, Sun J, Sutherland A, Hasty P, and Li R: (2009) Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. PLoS ONE, 4: e5034. Epub 2009 Apr 2. PMCID: PMC2661135.

Kang HJ, Kim HJ, Cho CH, Hu Y, Li R, and Bae I: (2008) BRCA1 transcriptional activity is enhanced by interactions between its AD1 domain and AhR. Cancer Chemother Pharmacol. 62: 965-75. PMCID: PMC2702208.

Sun J, Watkins G, Blair AL, Moskaluk C, Ghosh S, Jiang WG, and Li R: (2008) Deregulation of cofactor of BRCA1 expression in breast cancer cells. J Cell Biochem. 103: 1798-1807.

Aiyar SE, Cho H, Lee J, and Li R: (2007) Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells. Int J Biol Sci. 3: 486-92. PMCID: PMC2096739.

Sun J, Blair AL, Aiyar SE, and Li R: (2007) Cofactor of BRCA1 modulates androgen- dependent transcription and alternative splicing. J Steroid Biochem Mol Biol. 107: 131- 9. PMCID: PMC2701476.

Lu Y, Amleh A, Sun J, Jin X, McCullough SD, Baer R, Ren D, Li R* and Hu Y*: (2007) Ubiquitination and proteasome-mediated degradation of BRCA1 and BARD1 during steroidogenesis in human ovarian granulosa cells. Mol Endocrinol. 21: 651-63. (*co-corresponding authors).

Aiyar SE, Blair AL, Hopkinson DA, Bekiranov S, and Li R: (2007) Regulation of clustered gene expression by cofactor of BRCA1 (COBRA1) in breast cancer cells. Oncogene, 26: 2543-53.

Ghosh S, Lu Y, Katz A, Hu Y, and Li R: (2007) Tumor suppressor BRCA1 inhibits abreast cancer-associated promoter of the aromatase gene (CYP19) in human adipose stromal cells. Am J Physiol Endocrinol Metab. 292: E246-52.

McChesney PA, Aiyar SE, Lee OJ, Zaika A, Moskaluk C, Li R, and El-Rifai W: (2006) Cofactor of BRCA1: a novel transcription factor regulator in upper gastrointestinal carcinomas. Cancer Res. 66:1346-53.

Hu Y, Ghosh S, Amleh A, Yue W, Lu Y, Katz A, and Li R: (2005) Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression. Oncogene, 24: 8343-8.

Wu Y, Lu Y, Hu Y, and Li R: (2005) Cyclic AMP-dependent modification of gonad- selective TAF II 105 in a human ovarian granulosa cell line. J Cell Biochem. 96: 751-9.

Aiyar S, Sun JL, and Li R: (2005) BRCA1: a locus-specific “liaison” in gene expression and genetic integrity. J Cell Biochem. 94: 1103-11.

Ghosh S, Wu Y, Li R*, and Hu Y*: (2005) Jun proteins modulate the ovary-specific promoter of aromatase gene in ovarian granulosa cells via a cAMP-responsive element. Oncogene, 24: 2236-46. (*co-corresponding authors).

Loch CM, Mosammaparast N, Miyake T, Pemberton LF and Li R: (2004) Functional and physical interactions between ARS-binding factor 1 and the nuclear transport machinery. Traffic, 5: 925-35.

Yarragudi A, Miyake T, Li R, and Morse RH: (2004) Comparison of ABF1 and RAP1 inchromatin opening and transactivator potentiation in the budding yeast Saccharomyces cerevisiae. Mol Cell Biol. 24: 9152-64. PMCID: PMC517901.

Aiyar SE, Sun JL, Blair AL, Moskaluk CA, Lu YZ, Ye QN, Yamaguchi Y, Mukherjee A, Ren DM, Handa H, and Li R: (2004) Attenuation of estrogen receptor a-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev. 18: 2134-46. PMCID: PMC515291.

Miyake T, Reese J, Loch CM, Auble DT, and Li R: (2004) Genome-wide analysis of ARS binding factor 1 (Abf1p)-mediated transcriptional regulation in Saccharomyces cerevisiae. J Biol Chem. 279: 34865-72.

Fourel G, Miyake T, Defossez PA, Li R, and Gilson E: (2002) General regulatory factors (GRFs) as genome partitioners. J Biol Chem. 277: 41736-43.

Hu YF and Li R: (2002) JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction. Genes Dev. 16: 1509-17. PMCID: PMC186344.

Choudhary SK and Li R: (2002) BRCA1 modulates ionizing radiation-induced nuclear focus formation by the replication protein A p34 subunit. J Cell Biochem. 84: 666-74.

Miyake T, Loch CM, and Li R: (2002) Identification of a multifunctional domain in ARS-binding factor 1 required for transcriptional activation, DNA replication, and gene silencing. Mol Cell Biol. 22: 505-16. PMCID: PMC139751.

Ye Q, Hu YF, Zhong H, Nye AC, Belmont AS, and Li R: (2001) BRCA1-induced large- scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. JCell Biol. 155: 911-21. (highlighted in January 2002 issue of Nat Rev Cancer) PMCID: PMC2150890.

Melendy T and Li R*: (2001) Chromatin remodeling and initiation of DNA replication. Front Biosci. 6: D1048-53. (* corresponding author).

Lebrun E, Revardel E, Boscheron C, Li R, Gilson E, and Fourel G: (2001) Protosilencers in Saccharomyces cerevisiae subtelomeric regions. Genetics, 158: 167-76. PMCID:PMC1461618.

Fourel G, Boscheron C, Revardel E, Lebrun E, Hu YF, Simmen KC, Muller K, Li R, Mermod N, and Gilson E: (2001) An activation-independent role of transcription factors in insulator function. EMBO Rep. 2: 124-32. PMCID: PMC1083820.

Hu YF, Miyake T, Ye Q, and Li R: (2000) Characterization of a novel trans-activation domain of BRCA1 that functions in concert with the BRCA1 C-terminal (BRCT) domain. J Biol Chem. 275: 40910-5.

Miyake T, Hu YF, Yu DS, and Li R: (2000) A functional comparison of BRCA1 C-terminal domains in transcription activation and chromatin remodeling. J Biol Chem. 275: 40169-73.

Li R: (1999) Stimulation of DNA replication in Saccharomyces cerevisiae by aglutamine- and proline-rich transcriptional activation domain. J Biol Chem. 274: 30310-

Hu YF, Hao ZL, and Li R: (1999) Chromatin remodeling and activation of chromosomal DNA replication by an acidic transcriptional activation domain from BRCA1. Genes Dev. 13: 637-42. PMCID: PMC316546.

Guo CY, D’Anna JA, Li R, and Larner JM: (1999) The radiation-induced S-phase checkpoint is independent of CDKN1A. Radiat Res. 151: 125-32.

Li R*, Yu DS, Tanaka M, Zheng L, Berger SL, and Stillman B: (1998) Activation of chromosomal DNA replication in Saccharomyces cerevisiae by acidic transcriptional activation domains. Mol Cell Biol. 18: 1296-302. (* corresponding author). PMCID: PMC108842

Abramova NA, Russell J, Botchan M, and Li R: (1997) Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner. Proc Natl Acad Sci USA, 94: 7186-91. PMCID: PMC23787.